There are 2 prominent Johnny Depp memes that usually surface on social media often:

1. The meme where you can see Johnny Depp hugging a kid has been surfing the web for a lot of time. But very few know which is the movie where the meme is collected from.

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Name of the movie:

Finding Neverland

More about the movie:

johnny depp meme
Barrie forges a platonic bond with a widow, Sylvia, who has four kids. He is motivated to pen a play about a bunch of kids who do not desire to grow up, and this ends up bringing them closer.
Release date: 28 January 2005 (India)
Director: Marc Forster
Rating: 7.7/10 IMDb
Box office: 11.68 crores USD
Screenplay: David Magee
Best Achievement in Music Written for Motion Pictures, Original Score
Top 10 Film AAFC Award

2. One more famous Jhonny Depp meme is of him making weird faces in his funky Pirate’s dress. And everyone loves this character from his movie.

You guessed right, its:

Pirates of the Caribbean

More about the movie:

Pirates of the Caribbean
Pirates of the Caribbean is a series of fantasy swashbuckler films produced by Jerry Bruckheimer and based on Walt Disney’s theme park ride of the same name.
Box office: Total (5 films): $4,524,358,182
Produced by: Jerry Bruckheimer
Cast: Johnny Depp, Orlando Bloom, Keira Knightley
Characters: Jack Sparrow, Davy Jones, Hector Barbossa
Directors: Gore Verbinski, Rob Marshall, Joachim Rønning, Espen Sandberg

Some other memes from a mixture of movies:

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